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Antibodies
Anti-MDC1 antibody
Anti-MDC1 antibody from Abcam
Be the first to write a review!
Citations:
(36)
Supplier Page
Supplier Page from
Abcam for
Anti-MDC1 antibody
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
Anti-MDC1 antibody
Company
Abcam
Price
Pricing Info
Supplier Page
View Supplier Product Page
Catalog Number
ab11171
Antibody Type
Primary
Host
Rabbit
Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Immunoprecipitation, Western blot
Quantity
50 UG
Clonality
Polyclonal
Isotype
IgG
Conjugate/Tag
Unconjugated
Format
Antibodies were affinity purified using the peptide immobilized on solid support
Concentration
1 mg/ml
Gene Name
MDC1
Reactivity
Human
Target
MDC1
Add to Compare List
Abcam
Discovery Drive
Cambridge Biomedical Campus
Cambridge
CB2 0AX
United Kingdom
Phone
: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600
Company Profile
Website:
http://www.abcam.com
Citations (36)
(1)
The Fanconi anemia core complex promotes CtIP-dependent end-resection to drive homologous recombination at DNA double-strand breaks
bioRxiv
November 20, 2023
Bert van de Kooij, Fenna J. van der Wal, Magdalena B. Rother, Pau Creixell, Merula Stout, Wouter Wiegant, Brian A. Joughin, Julia Vornberger, Marcel A.T.M. van Vugt, Matthias Altmeyer,
et al.
clone
DM1A",WB (
1:5000
) gH2AX,
Mouse
,
Millipore
,"#
05-636
,
clone
JBW301",IF (
1:2000
) MDC1,Rabbit,
Abcam
,
ab11171
-50,WB (
1:1000
) pRPA (S4/S8),Rabbit,
Bethyl
,
A300-245A
,IF (
1:1000
)
Rad51
,
Mouse
,
Genetex
,"
GTX70230
,
Clone
(2)
Chromatin-Associated SIN3B Protects Cancer Cells from Genotoxic Stress-Induced Apoptosis and Dictates DNA Damage Repair Pathway Choice
Molecular cancer research : MCR
September 1, 2023
Morales-Valencia J, Petit C, Calderon A, Saini S, David G.
anti-Chk2 (
Cell Signaling
,
2662T
), rabbit anti-pChk2 (
Cell Signaling
,
2661T
), rabbit anti-MDC1 (
Abcam
Cat#
ab11171
), mouse anti-Lamin A/C (
Santa Cruz Biotechnology
Cat#
sc-376248
). Each experiment was performed at least
(3)
ATM-ESCO2-SMC3 axis promotes 53BP1 recruitment in response to DNA damage and safeguards genome integrity by stabilizing cohesin complex
Nucleic acids research
August 11, 2023
Fu J, Zhou S, Xu H, Liao L, Shen H, Du P, Zheng X.
polyclonal anti-53BP1 (IF
1:200
,
sc-22760
,
Santa Cruz Biotechnology
), rabbit polyclonal anti-MDC1 (
1:1000
,
ab11171
,
Abcam
), rabbit polyclonal anti-BRCA1 (IF
1:100
,
BS6423
,
Bioworld
), polyclonal anti-γH2AX (IF
1:200
,
(4)
Heritable transcriptional defects from aberrations of nuclear architecture
Nature
July 1, 2023
Papathanasiou S, Mynhier NA, Liu S, Brunette G, Stokasimov E, Jacob E, Li L, Comenho C, van Steensel B, Buenrostro JD,
et al
.
phospho γH2AX (Ser139) (
Millipore
,
05-636-I
;
1:400
); H3K27ac (
Active Motif
,
39133
;
1:200
);
MDC1
(
Abcam
,
ab11171
;
1:1,000
);
MDC1
(
Sigma-Aldrich
,
M2444
;
1:1,000
); phospho RNA PolII S5 (
Millipore
,
MABE954
,
clone
1H4B6;
(5)
Mitotic clustering of pulverized chromosomes from micronuclei
Nature
June 1, 2023
Lin YF, Hu Q, Mazzagatti A, Valle-Inclán JE, Maurais EG, Dahiya R, Guyer A, Sanders JT, Engel JL, Nguyen G,
et al
.
Santa Cruz),
1:1,000
anti-phosphorylated
histone H3
(Ser10) (
06-570
,
Millipore
) and
1:5,000
anti-MDC1 (
ab11171
,
Abcam
). The blots were incubated with
1:4,000
dilutions of
horseradish
peroxidase-conjugated
goat
anti-rabbit
(6)
Mitotic tethering enables inheritance of shattered micronuclear chromosomes
Nature
June 1, 2023
Trivedi P, Steele CD, Au FKC, Alexandrov LB, Cleveland DW.
(
Bethyl Laboratories
,
A300–111A
,
1:2000
IF,
1:2000
IB) (
Abcam
,
ab2402
,
1:1000
IF), anti-MDC1 (
Abcam
ab11171
,
1:1000
IF,
1:1000
IB),
anti-CIP2A
(
clone
2G10–3B5;
Santa Cruz
sc80659
,
1:500
IF,
1:1000
IB), anti-GAPDH
(7)
Multi-layered chromatin proteomics identifies cell vulnerabilities in DNA repair
Nucleic acids research
January 25, 2023
Sigismondo G, Arseni L, Palacio-Escat N, Hofmann TG, Seiffert M, Krijgsveld J.
Reagents,Source,Identifier Antibodies,Antibodies,Antibodies
Human
RPA,
Santa Cruz Biotechnology
,
sc4842
Human
MDC1,
Abcam
,
ab11171
Human
RAD50
,
GeneTex
,
GTX70228
Human
THRAP3
,
Novus Biologicals
,
NB100-40848
Human RAD51,Merk Millipore,PC130
Human
(8)
The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis
Nature communications
July 16, 2022
De Marco Zompit M, Esteban MT, Mooser C, Adam S, Rossi SE, Jeanrenaud A, Leimbacher PA, Fink D, Shorrocks AK, Blackford AN,
et al
.
1:5000
), GFP (Rabbit,
Abcam
,
ab290
,
1:1000
), HA (Rabbit,
Abcam
,
ab9110
,
1:4000
), MDC1 (Rabbit,
Abcam
,
ab11171
,
1:5000
), MDC1 pSer168 (Rabbit, AMS Biotechnology, custom-made,
1:500
)11, MDC1 pSer196 (Rabbit, 21st
(9)
cGAS guards against chromosome end-to-end fusions during mitosis and facilitates replicative senescence
Protein & cell
January 1, 2022
Li X, Li X, Xie C, Cai S, Li M, Jin H, Wu S, Cui J, Liu H, Zhao Y.
fluorescence microscopy
. Antibodies used are as follows: anti-cGAS (
1:100
, CST), anti-
53BP1
(
1:2,000
,
NB100-304
,
Novus
), MDC1 (
1:400
,
ab11171
,
Abcam
), anti-
RNF8
(
1:100
, Santa Cruz), anti-CDK1 (
1:200
, Abcam), anti-γH2AX antibody (
1:400
, CST),
(10)
Mice with Whole-Body Disruption of AMPK-Glycogen Binding Have Increased Adiposity, Reduced Fat Oxidation and Altered Tissue Glycogen Dynamics
International Journal of Molecular Sciences
September 5, 2021
Natalie R. Janzen, Jamie Whitfield, Lisa Murray-Segal, Bruce E. Kemp, John A. Hawley, Nolan J. Hoffman
p-S641,
1:1000
,4 °C,
1:5000
GS,
CST
3886
,Overnight,GAR CST
7074
GS,
1:1000
,4 °C,
1:5000
Glycogenin1,
Abcam
ab11171
,Overnight,GAR CST
7074
Glycogenin1,
1:1000
,4 °C,
1:2000
GBE1
,
Abcam
ab180596
,Overnight,GAR CST
7074
GBE1
,
1:1000
,4
(11)
Mediator of DNA Damage Checkpoint 1 (MDC1) Is a Novel Estrogen Receptor Coregulator in Invasive Lobular Carcinoma of the Breast
Molecular cancer research : MCR
August 1, 2021
Sottnik JL, Bordeaux EK, Mehrotra S, Ferrara SE, Goodspeed AE, Costello JC, Sikora MJ.
(4% paraformaldehyde) and permeabilized (0.1% Triton X-100) prior to antibody
incubation
(
MDC1
:
Abcam
Ab11171
, RRID:AB_297810,
1:2000
; yH2AX:
Sigma
05-636
, RRID:AB_310795,
1:400
) in 3% BSA overnight. Wells were
(12)
Herpes Simplex Virus 1 Manipulates Host Cell Antiviral and Proviral DNA Damage Responses
mBio
February 9, 2021
Mertens ME, Knipe DM.
,
Cell Signaling
,
9284S
,"
1:1,000
" Anti-phospho-p53 (S20),
Invitrogen
,
PA5-17894
,"
1:1,000
" Anti-ICP0,
East Coast
Bio,
H1A027
,"
1:2,000
" Anti-Mdc1,
Abcam
,
ab11171
,"
1:2,000
" Anti-ICP8,93,,"
1:5,000
" Anti-FLAG,
Sigma
,
F1804
,"
1:2,000
" Anti-
Mre11
,
Novus Biologicals
,
NB100-142
,"
1:2,000
" Anti-ICP4,94,,"
1:2,000
" Anti-53BP1,
Abcam
,
ab21083
,"
1:1,000
" Anti-DNA-PKcs,
Abcam
,
ab70250
,"
1:2,000
" Anti-IFI16,
Abcam
,
ab55328
,"
1:1,000
" Anti-rabbit
(13)
Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1A
Cell reports
January 26, 2021
Lee KY, Dutta A.
(
04–263
) (
EMD Millipore
); anti-pS1981-ATM (
ab81292
), anti-ATM (
ab78
), anti-H3 (
ab1791
), anti-MDC1 (
ab11171
), anti-MDC1 (
ab50003
), and anti-
RNF8
(
ab105362
) (
Abcam
)
Immunofluorescence
Immunofluorescence
was
(14)
CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks
Nature communications
November 13, 2020
Rother MB, Pellegrino S, Smith R, Gatti M, Meisenberg C, Wiegant WW, Luijsterburg MS, Imhof R, Downs JA, Vertegaal ACO,
et al
.
sc-9034
)",,
1:2000
LIG3,Rabbit,
Abcam
(
ab96576
),,
1:1000
LIG4
,Rabbit,
Abcam
(
ab193353
),
1:100
, MDC1,Rabbit,
Abcam
(
ab11171
-50),
1:1000
, p53,
Mouse
,Santa Cruz (
clone
DO-1),,
1:1000
PAR,Rabbit,Enzo Lifesciences,
1:1000
,
1:2000
PARP1
,Rabbit,
Cell Signaling
(15)
The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency
Cell reports
August 4, 2020
Gatti M, Imhof R, Huang Q, Baudis M, Altmeyer M.
BioAcademia;
1:1000
for IF), XRCC1 (
mouse
,
H00007515-B01P
,
Novus Biologicals
;
1:500
for IF), MDC1 (rabbit,
ab11171
,
Abcam
,
1:1000
for IF), RPA70 (rabbit,
ab79398
,
Abcam
, IF
1:500
for IF), RNF168 (rabbit,
1:2000
for WB
(16)
Low dose ionizing radiation strongly stimulates insertional mutagenesis in a γH2AX dependent manner
PLoS genetics
January 1, 2020
Zelensky AN, Schoonakker M, Brandsma I, Tijsterman M, van Gent DC, Essers J, Kanaar R.
(
Novus Biologicals
,
NB100-304
),
H2AX
(Cell Signaling, #
2595
), γH2AX (pS139, Millipore JBW301), MDC1 ("exon8”,
Abcam
,
ab11171
and P2B11,
Millipore
,
05–1572
),
MCPH1
(
Cell Signaling
, #
4120
), Cyclin A (Santa Cruz, C-19), PARP-1 (ENZO,
(17)
Double-strand breaks in ribosomal RNA genes activate a distinct signaling and chromatin response to facilitate nucleolar restructuring and repair
Nucleic acids research
September 5, 2019
Korsholm LM, Gál Z, Lin L, Quevedo O, Ahmad DA, Dulina E, Luo Y, Bartek J, Larsen DH.
immunofluorescence (IF
) in this study were:
mouse
γH2AX (
Millipore
, #
16–193
,
1:250
), rabbit
MDC1
(
Abcam
, #
ab11171
–50,
1:1000
), rabbit
TCOF1
(
Sigma
Life Science, #
HPA038237
,
1:200
),
mouse
Mre11 (
Abcam
, #
ab214
,
1:500
),
(18)
PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage
Cancer discovery
September 1, 2019
Zhang J, Lee YR, Dang F, Gan W, Menon AV, Katon JM, Hsu CH, Asara JM, Tibarewal P, Leslie NR,
et al
.
Anti-HA (MMS-101P) was obtained from Covance. Anti-MMSET/NSD2 (
ab75359
) and anti-MDC1 (
ab41951
and
ab11171
) were purchased form the
Abcam
. Anti-
53BP1
(
612523
) was obtained from the
BD Biosciences
. The polyclonal
(19)
Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation
Molecular cell
August 8, 2019
Rabl J, Bunker RD, Schenk AD, Cavadini S, Gill ME, Abdulrahman W, Andrés-Pons A, Luijsterburg MS, Ibrahim AFM, Branigan E,
et al
.
washes were
in WB
. The primary antibodies (
mouse
BRCA1
Santa Cruz
sc-6954
; 1/100, and rabbit MDC1
Abcam
ab11171
; 1/1000) were incubated overnight at 4°C. Detection was done using
goat
anti-
mouse
or
goat
anti-rabbit
(20)
MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis
Molecular cell
May 2, 2019
Leimbacher PA, Jones SE, Shorrocks AK, de Marco Zompit M, Day M, Blaauwendraad J, Bundschuh D, Bonham S, Fischer R, Fink D,
et al
.
Santa Cruz Biotechnology
, 1/1000),
KAP1
(
ab10483
,
Abcam
, 1/5000),
KAP1
-pS824 (
IHC-00073
,
Bethyl Laboratories
, 1/500), MDC1 (
ab11171
,
Abcam
, 1/5000), MDC1-pS168 (1/500), MDC1-pS196 (1/2000),
NBS1
(
ab32074
,
Abcam
, 1/2000), RAD9 (
ab70810
,
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Anti-MDC1 antibody from Abcam
Supplier Page
View Supplier Product Page
Pricing Info
Product Specs
Company Info
Citations
Reviews
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